Human FBN1 Recombinant Protein (C-Fc) (HW833011)

Name: Human FBN1 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HW833011
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	HW833011
Description	Recombinant Human FBN1 Protein, C-Fc (HW833011) expressed in Mammalian Cells, spanning Ser2732-His2871. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	P35555
Protein length	Ser2732-His2871
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	44.59 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Asprosin, FBN, FBN1, Fibrillin-1
Background	Fibrillin-1 is a ~312 kDa protein. Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components. 1. Lee, SS. et al. (2004) Structure (London, England : 1993) 12, 717-29. PMID: 15062093 2. Sakai, LY. et al. (1991) The Journal of biological chemistry 266, 14763-70. PMID: 1860873 3. Jensen, SA. et al. (2016) The Biochemical journal 473, 827-38. PMID: 27026396 4. Tiedemann, K. et al. (2013) Journal of cell science 126, 4187-94. PMID: 24039232 5. Bax, DV. et al. (2003) The Journal of biological chemistry 278, 34605-16. PMID: 12807887 6. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881
Note	For research use only

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Datasheet

Human FBN1 Recombinant Protein (C-Fc).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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C₁ × V₁ = C₂ × V₂

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C₁ (Stock Conc.)

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Human FBN1 Recombinant Protein (C-Fc) (HW833011)

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