Human FZR1 Recombinant Protein (N-His) (HP589022)

Name: Human FZR1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HP589022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HP589022
Description	Recombinant Human FZR1 Protein, N-His (HP589022) expressed in E. coli, spanning Ser172-Arg496. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9UM11
Protein length	Ser172-Arg496
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	38.25 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CDC20-like protein 1, CDH1, Cdh1/Hct1 homolog, FYR, FZR, FZR1, Fizzy-related protein homolog, Fzr, KIAA1242, hCDH1
Background	Fizzy-related protein homolog is a ~55 kDa protein. Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. 1. Lafranchi, L. et al. (2014) The EMBO journal 33, 2860-79. PMID: 25349192
Note	For research use only

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Datasheet

Human FZR1 Recombinant Protein (N-His).pdf

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Human FZR1 Recombinant Protein (N-His) (HP589022)

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