Human IRF1 Recombinant Protein (N-His) (HY164042)

Name: Human IRF1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HY164042
Price: 211 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug
1mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.	HY164042
Description	Recombinant Human IRF1 Protein, N-His (HY164042) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	P10914
Protein length	Met1-Pro114
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	IRF-1, IRF1, Interferon regulatory factor 1
Background	Interferon regulatory factor 1 is a ~36 kDa protein. Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Has an essentail role in IFNG-dependent immunity to mycobacteria. Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters. 1. Oshima, S. et al. (2004) Molecular and cellular biology 24, 6298-310. PMID: 15226432 2. Dornan, D. et al. (2004) Molecular and cellular biology 24, 10083-98. PMID: 15509808 3. Su, ZZ. et al. (2007) Journal of cellular physiology 213, 502-10. PMID: 17516545 4. Park, J. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 17028-33. PMID: 17942705 5. Bowie, ML. et al. (2008) Advances in experimental medicine and biology 617, 367-74. PMID: 18497060 6. Huang, Y. et al. (2009) PloS one 4, e5397. PMID: 19404407 7. Gao, J. et al. (2010) Cell death and differentiation 17, 699-709. PMID: 19851330 8. Qi, H. et al. (2012) The Journal of biological chemistry 287, 12622-33. PMID: 22367195 9. Somerville, TDD. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 11471-11482. PMID: 32385160 10. Tanaka, N. et al. (1993) Molecular and cellular biology 13, 4531-8. PMID: 7687740
Note	For research use only