Human NKX2-5 Recombinant Protein (N-GST & C-His) (HW502022)

Name: Human NKX2-5 Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HW502022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HW502022
Description	Recombinant Human NKX2-5 Protein, N-GST & C-His (HW502022) expressed in E. coli, spanning Asp105-Leu207. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P52952
Protein length	Asp105-Leu207
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	40.59 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CSX, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, NKX2-5, NKX2.5, NKX2E
Background	Homeobox protein Nkx-2.5 is a ~34 kDa protein. Transcription factor required for the development of the heart and the spleen. During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4. May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal. Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression. 1. Koss, M. et al. (2012) Developmental cell 22, 913-26. PMID: 22560297 2. Pradhan, L. et al. (2012) Biochemistry 51, 6312-9. PMID: 22849347 3. Pradhan, L. et al. (2016) Biochemistry 55, 1702-10. PMID: 26926761 4. Samokhin, AO. et al. (2018) Science translational medicine 10. PMID: 29899023
Note	For research use only

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Datasheet

Human NKX2-5 Recombinant Protein (N-GST & C-His).pdf

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Human NKX2-5 Recombinant Protein (N-GST & C-His) (HW502022)

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