

| Catalog No. | HD282012 |
|---|---|
| Description |
Recombinant Human PYDC2 Protein, N-His (HD282012) expressed in E. coli, spanning Met1-Pro97. Purity: >90% by SDS-PAGE.
Highlights
|
| Expression system | E. coli |
| Accession | Q56P42 |
| Protein length | Met1-Pro97 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Species | Homo sapiens (Human) |
| Nature | Recombinant |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >90% as determined by SDS-PAGE. |
| Predicted molecular weight | 12.96 kDa |
| Form | Lyophilized |
| Storage buffer | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Shipping | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Alternate Names | POP2, PYDC2, Pyrin domain-containing protein 2, Pyrin-only protein 2, cPOP2, cellular POP2 |
| Background | Pyrin domain-containing protein 2 is a ~10 kDa protein. May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome. May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA. 1. Dorfleutner, A. et al. (2007) Infection and immunity 75, 1484-92. PMID: 17178784 2. Bedoya, F. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 178, 3837-45. PMID: 17339483 3. Porter, KA. et al. (2014) Genes and immunity 15, 392-403. PMID: 24871464 |
| Note | For research use only |
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