Human TSPAN4 Recombinant Protein (N-His) (HD423012)

Name: Human TSPAN4 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD423012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD423012
Description	Recombinant Human TSPAN4 Protein, N-His (HD423012) expressed in E. coli, spanning Tyr107-Asn201. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O14817
Protein length	Tyr107-Asn201
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	13.23 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	NAG-2, NAG2, Novel antigen 2, TM4SF7, TSPAN4, Tetraspanin-4, Transmembrane 4 superfamily member 7, Tspan-4
Background	Tetraspanin-4 is a ~26 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays an essential role in migrasome formation and migration on retracting fibers at the rear end of migrating cells. Migrasomes are cellular organelles that form as large vesicle-like structures on retraction fibers of migrating cells. Mechanistically, acts as a membrane curvature sensor and participates in stabilizing the migrasome structure in a late stage of biogenesis. May also play a regulatory role for the histamine H4 receptor/HRH4 without affecting histamine binding to HRH4 or signaling. 1. Huang, Y. et al. (2019) Nature cell biology 21, 991-1002. PMID: 31371828 2. Dharan, R. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2208993119. PMID: 36252000 3. Dharan, R. et al. (2023) Nature communications 14, 1037. PMID: 36823145 4. Ma, X. et al. (2021) Biomolecules 11. PMID: 34439793
Note	For research use only

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Datasheet

Human TSPAN4 Recombinant Protein (N-His).pdf

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Human TSPAN4 Recombinant Protein (N-His) (HD423012)

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