Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Interleukin-4 receptor subunit alpha is a ~87 kDa protein. Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Note
For research use only
Images
Bioactivity
Detected by REGN1103 (Catalog No: MB732013) in indirect ELISA.
Bioactivity
Immobilized MB732011 Mouse CD124/IL4R Recombinant Protein (C-Fc) at 2 μg/mL(100 μL/well) can bind MY457011 Mouse IL4 Recombinant Protein (N-mFc), the EC 50 is 127 ng/mL.
Bioactivity
Immobilized MY457011 Mouse IL4 Recombinant Protein (N-mFc) at 2 μg/mL(100 μL/well) can bind MB732011 Mouse CD124/IL4R Recombinant Protein (C-Fc), the EC 50 is 156 ng/mL.
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