Mouse CD226/DNAM-1 Recombinant Protein (C-Fc) (MS737021)

Name: Mouse CD226/DNAM-1 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: MS737021
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	MS737021
Description	Recombinant Mouse CD226/DNAM-1 Protein, C-Fc (MS737021) expressed in Mammalian Cells, spanning Glu19-Pro254. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	Q8K4F0
Protein length	Glu19-Pro254
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	55.12 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CD226, CD226 antigen, DNAM-1, DNAM1, DNAX accessory molecule 1
Background	CD226 antigen is a ~38 kDa protein. Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells. Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells. Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes. 1. Iguchi-Manaka, A. et al. (2008) The Journal of experimental medicine 205, 2959-64. PMID: 19029379 2. Chan, CJ. et al. (2014) Nature immunology 15, 431-8. PMID: 24658051 3. Zhang, Z. et al. (2015) The Journal of experimental medicine 212, 2165-82. PMID: 26552706 4. Wang, H. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 988-996. PMID: 30591568
Note	For research use only

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Datasheet

Mouse CD226/DNAM-1 Recombinant Protein (C-Fc).pdf

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Mouse CD226/DNAM-1 Recombinant Protein (C-Fc) (MS737021)

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