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Anti-Canine CTLA-4 Reference Antibody (39A11, RUO) (CB651026)

Anti-Canine CTLA-4 Reference Antibody (39A11, RUO)
Anti-Canine CTLA-4 Reference Antibody (39A11, RUO)
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Overview
Catalog No.CB651026
Description
Anti-Dog CD152/CTLA4 Antibody (39A11) (CB651026) is a research-grade recombinant antibody targeting CD152. Produced in mammalian cells with native-like glycosylation.
Highlights
  • Research Grade — For PK/PD studies, assay development, and ADA research.
  • Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivityCanine
ApplicationsELISA, Bioactivity: FCM, Functional assay, Research in vivo
Host speciesCanine
ClonalityMonoclonal
IsotypeIgG2, kappa
Clone ID39A11
Target HA, Hemagglutinin, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain
Endotoxin level < 10 EU/mg
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession Q9XSI1
Form Liquid
Storage buffer 0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Cytotoxic T-lymphocyte protein 4 (CD152/CTLA4) is a ~24 kDa protein. Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. CD152 is the therapeutic target of ipilimumab (Yervoy).

Note For research use only. Not suitable for clinical or therapeutic use.
Images
  • Anti-Canine CTLA-4 Reference Antibody (39A11, RUO)

    SDS-PAGE

    SDS-PAGE for Research Grade Anti-Dog CD152/CTLA4 Antibody (39A11)

References
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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