Anti-HIV1 gp120/Glycoprotein 120 Reference Antibody (VRC01LS, RUO) (VK617066)

Name: Anti-HIV1 gp120/Glycoprotein 120 Reference Antibody (VRC01LS, RUO)
Brand: abinScience
SKU: VK617066
Price: 176 USD
Availability: InStock

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References
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Overview

Catalog No.	VK617066
Species reactivity	Human immunodeficiency virus 1 (HIV-1)
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	VRC01LS
Expression system	Mammalian cells
Clonality	Monoclonal
Target	gp120/Glycoprotein 120
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q03805
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	VRC01LS
Background	Envelope glycoprotein gp160 (gp120/Glycoprotein 120) is a ~96 kDa protein. Envelope glycoprotein gp160: Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41.
References	1. Happe M, et al. Virologic effects of broadly neutralizing antibodies VRC01LS and VRC07-523LS on chronic HIV-1 infection. JCI Insight. 2025 Feb 24;10(4):e181496. [VK617066] 2. Gaudinski MR, et al. Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults. PLoS Med. 2018 Jan 24;15(1):e1002493. [VK617066]
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects recombinant HIV1 gp120 (Catalog No: VK617011) in indirect ELISA.
Bioactivity

Detects recombinant HIV1 gp120 (Catalog No: VK617021) in indirect ELISA.