Anti-Human CD117/c-kit Reference Antibody (CDX-0158, RUO) (HY163086)

Name: Anti-Human CD117/c-kit Reference Antibody (CDX-0158, RUO)
Brand: abinScience
SKU: HY163086
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HY163086
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	CDX-0158
Biological activity	CDX-0158 induces FcγR-dependent degranulation in IFNγ -pretreated primary human mast cells [2]. CDX-0158 elicits potent ADCC activity against M-07e cells in a reporter-based assay [2]. CDX-0158 depletes the majority of skin mast cells in healthy dogs within 2 weeks, with remaining mast cells showing evidence of apoptosis [2].
Expression system	Mammalian cells
Target	Mast/stem cell growth factor receptor Kit, p145 c-kit, Tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, KIT, PBT, Piebald trait protein, Proto-oncogene c-Kit, SCFR, CD117
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P10721
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CDX-0158, CDX0158, CDX0158
Background	Mast/stem cell growth factor receptor Kit (CD117) is a ~109 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1.
References	1. Eggel A, et al. Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways. Immunol Rev. 2024;328(1):387-411. [HY163086] 2. Alvarado D, et al. Anti-KIT monoclonal antibody CDX-0159 induces profound and durable mast cell suppression in a healthy volunteer study. Allergy. 2022;77(8):2393-2403. [HY163086]
Note	For research use only. Not suitable for clinical or therapeutic use.