Anti-Human Fc gamma RIIIA/CD16a2/SELPLG/PSGL-1 Reference Antibody (VTX 0811, RUO) (HC298036)

Name: Anti-Human Fc gamma RIIIA/CD16a2/SELPLG/PSGL-1 Reference Antibody (VTX 0811, RUO)
Brand: abinScience
SKU: HC298036
Price: 326 USD
Availability: InStock

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Overview

Catalog No.	HC298036
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	VTX 0811
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Selectin P ligand, PSGL-1, SELPLG, CD162, P-selectin glycoprotein ligand 1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q14242
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	VTX-0811, VTX0811, VTX0811
Background	P-selectin glycoprotein ligand 1 (CD162/SELPLG) is a ~43 kDa protein. A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
References	1. Feldman I, et al. VTX-0811, a first-in-class PSGL-1 blocking monoclonal antibody, repolarizes tumor associated macrophages and induces inflammation in the tumor microenvironment, leading to suppression of tumor growth in pre-clinical studies[J]. Cancer Research, 2022, 82(12_Supplement): 5602-5602. [HC298036]
Note	For research use only. Not suitable for clinical or therapeutic use.