Anti-Human CD266/TNFRSF12A Reference Antibody (BAY-356, RUO) (HV811026)

Name: Anti-Human CD266/TNFRSF12A Reference Antibody (BAY-356, RUO)
Brand: abinScience
SKU: HV811026
Price: 326 USD
Availability: InStock

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Overview

Catalog No.	HV811026
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	BAY-356
Biological activity	BAY-356 induces dose-dependent agonistic effects in TWEAK receptor-positive tumor cells, activating NFκB and STAT1 pathways, increasing TWEAKR expression and IL-8 secretion, activating caspase 3/7, and inhibiting proliferation [1]. BAY-356 (3-10 mg/kg; twice weekly; up to 3 weeks) inhibits tumor growth by 49-71% in TWEAK receptor-positive solid tumor xenograft models [1]. BAY-356 (1-40 mg/kg; i.v.; weekly; 4 weeks) at 10 mg/kg results in well-tolerated exposure in healthy Cynomolgus monkeys, with higher doses (20 and 40 mg/kg) causing slight to moderate organ toxicity [2].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	FGF-inducible 14, TNFRSF12A, FN14, CD266, TweakR, Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, Tumor necrosis factor receptor superfamily member 12A
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9NP84
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BAY-356, BAY356, BAY356
Background	Tumor necrosis factor receptor superfamily member 12A (CD266/TNFRSF12A) is a ~13 kDa protein. Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
References	1. Berndt S, et al. Abstract 1210: Preclinical pharmacology and repeated dose toxicity of the novel agonistic TWEAK receptor binding antibody BAY-356. Cancer Res. 2016;76(14_Supplement):1210. [HV811026] 2. Viberg A, et al. Abstract 2089: Therapeutic index prediction of the agonistic aglycosylated TWEAK receptor binding antibody BAY-356. Cancer Res. 2016;76(14_Supplement):2089. [HV811026]
Note	For research use only. Not suitable for clinical or therapeutic use.