Anti-Human CD277/BTN3A1 Reference Antibody (CTX 2026, RUO) (HT139016)

Name: Anti-Human CD277/BTN3A1 Reference Antibody (CTX 2026, RUO)
Brand: abinScience
SKU: HT139016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HT139016
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG2
Clone ID	CTX 2026
Biological activity	CTX-2026 (1 ug/mL; 12 h) redirects the cytotoxic activity of Vγ9Vδ2 T cells from multiple donors against BTN3A1 + OVCAR3 cells or primary HGSOC cells [1]. CTX-2026 (1 ug/mL; 6 d) shows a rescuing effect on nonablated CD45 + T cells [1]. CTX-2026 (5 mg/kg; i.p. for 15 days every 3 days once) effects the tumor growth of NY-OVCAR3 tumor mice [1].
Expression system	Mammalian cells
Clonality	Monoclonal
Target	BTF5, BTN3A1, Butyrophilin subfamily 3 member A1, CD277
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O00481
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CTX-2026
Background	Butyrophilin subfamily 3 member A1 (CD277/BTN3A1) is a ~57 kDa protein. Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
References	1. Payne KK, et al. BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells. Science. 2020 Aug 21;369(6506):942-949. [HT139016]
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD277/BTN3A1 Antibody (CTX 2026)

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Datasheet

Anti-Human CD277/BTN3A1 Reference Antibody (CTX 2026, RUO).pdf

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Anti-Human CD277/BTN3A1 Reference Antibody (CTX 2026, RUO) (HT139016)

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