Anti-Human CD43 Reference Antibody (AT1413, RUO) (HB263026)

Name: Anti-Human CD43 Reference Antibody (AT1413, RUO)
Brand: abinScience
SKU: HB263026
Price: 326 USD
Availability: InStock

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Overview

Catalog No.	HB263026
Description	Anti-Human CD43/SPN/Leukosialin (AT1413) (HB263026) is a research-grade recombinant antibody targeting CD43. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Clone ID	AT1413
Expression system	Mammalian cells
Clonality	Monoclonal
Target	GPL115, Leukocyte sialoglycoprotein, Leukosialin, Sialophorin, SPN, Galactoglycoprotein, CD43, CD43ct, CD43-ct, GALGP
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P16150
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	AT1413
Background	Leukosialin (CD43/SPN) is a ~40 kDa protein. Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. 1. Ramírez-Pliego, O. et al. (2007) BMC immunology 8, 30. PMID: 18036228 2. Galindo-Albarrán, AO. et al. (2014) Journal of cellular physiology 229, 172-80. PMID: 24328034
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human CD43/SPN/Leukosialin (AT1413)

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Datasheet

Anti-Human CD43 Reference Antibody (AT1413, RUO).pdf

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Anti-Human CD43 Reference Antibody (AT1413, RUO) (HB263026)

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