Anti-Human AG-7 Antigen Reference Antibody (AbGn-107, RUO) (HY036106)

Name: Anti-Human AG-7 Antigen Reference Antibody (AbGn-107, RUO)
Brand: abinScience
SKU: HY036106
Price: 176 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HY036106

Description

Anti-Human CD71/TFRC (AbGn-107) (HY036106) is a research-grade recombinant antibody targeting CD71. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Species reactivity

Human

Applications

ELISA, Bioactivity: FCM, Functional assay, Research in vivo

Host species

Human

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone ID

AbGn-107

Target

AG-7, Lewis A-like glycol-epitope

Endotoxin level

< 10 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Form

Liquid

Storage buffer

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

AbGn-107, AbGn107, AbGn107

Background

Transferrin receptor protein 1 (CD71/TFRC) is a ~84 kDa protein. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the hereditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

1. Senyilmaz, D. et al. (2015) Nature 525, 124-8. PMID: 26214738

2. Jabara, HH. et al. (2016) Nature genetics 48, 74-8. PMID: 26642240

Note

For research use only. Not suitable for clinical or therapeutic use.

Isotype Control

Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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