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Research Grade hEPO-Fc (HB152016)

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Overview
Catalog No.HB152016
Description
Anti-Human EPOR (rhEPO-Fc) (HB152016) is a research-grade recombinant antibody targeting EPOR. Produced in mammalian cells with native-like glycosylation.
Highlights
  • Research Grade — For PK/PD studies, assay development, and ADA research.
  • Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivityHuman
ApplicationsFunctional assay
Host speciesHuman
Expression system Mammalian cells
Species Homo sapiens (Human)
Target EPOR, Erythropoietin receptor, EPO-R
Endotoxin level < 10 EU/mg
Purity >95% purity as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P01588
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Erythropoietin receptor (EPOR) is a ~55 kDa protein. Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.

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1. Zhan, H. et al. (1999) Protein engineering 12, 505-13. PMID: 10388848
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2. Winkelmann, JC. et al. (1990) Blood 76, 24-30. PMID: 2163695
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3. Jones, SS. et al. (1990) Blood 76, 31-5. PMID: 2163696
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4. Middleton, SA. et al. (1996) The Journal of biological chemistry 271, 14045-54. PMID: 8662939
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5. Syed, RS. et al. (1998) Nature 395, 511-6. PMID: 9774108
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6. Kirito, K. et al. (2002) Blood 99, 102-10. PMID: 11756159
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Note For research use only. Not suitable for clinical or therapeutic use.
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Formula
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