Anti-Human EPOR Reference Antibody (rhEPO-Fc, RUO) (HB152016)

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Overview

Catalog No.	HB152016
Description	Anti-Human EPOR (rhEPO-Fc) (HB152016) is a research-grade recombinant antibody targeting EPOR. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	rhEPO-Fc
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	EPOR, Erythropoietin receptor, EPO-R
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P19235
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	rhEPO-Fc
Background	Erythropoietin receptor (EPOR) is a ~55 kDa protein. Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. 1. Zhan, H. et al. (1999) Protein engineering 12, 505-13. PMID: 10388848 2. Winkelmann, JC. et al. (1990) Blood 76, 24-30. PMID: 2163695 3. Jones, SS. et al. (1990) Blood 76, 31-5. PMID: 2163696 4. Middleton, SA. et al. (1996) The Journal of biological chemistry 271, 14045-54. PMID: 8662939 5. Syed, RS. et al. (1998) Nature 395, 511-6. PMID: 9774108 6. Kirito, K. et al. (2002) Blood 99, 102-10. PMID: 11756159
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human EPOR (rhEPO-Fc)

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Anti-Human EPOR Reference Antibody (rhEPO-Fc, RUO).pdf

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Anti-Human EPOR Reference Antibody (rhEPO-Fc, RUO) (HB152016)

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