Research Grade DF6002 (HB769106)

Name: Research Grade DF6002
Brand: abinScience
SKU: HB769106
Price: 326 USD
Availability: InStock

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Overview

Catalog No.	HB769106
Applications	Functional assay
Clone ID	DF6002
Biological activity	DF6002 (200 nM) specifically binds to IL-12 receptor-expressing CD4 + T cells, CD8 + T cells, NK cells, and weakly to B cells in activated human PBMCs [1]. DF6002 (0.00596-6250 pM; 72 h) induces IFN-γ production in activated human PBMCs with an EC 50 of 2.99 pM [1]. DF6002 (200 nM) specifically binds to IL-12 receptor-expressing CD4 + T cells, CD8 + T cells, NK cells, and weakly to B cells in activated cynomolgus monkey PBMCs [1]. DF6002 (0.00596-6250 pM; 72 h) induces IFN-γ production in activated cynomolgus monkey PBMCs with an EC 50 of 6.91 pM [1]. Parmacokinetics Species Dose Route T 1/2 Cynomolgus Monkey [1] 1 mg/kg i.v. 17.4-30.5 h DF6002 (1-19 ug/kg; i.v.) exhibits prolonged in vivo half-life in cynomolgus monkeys, induces a sustained, potent IFNγ response at 1 ug/kg, and is well tolerated at doses up to 19 ug/kg [1].
Expression system	Mammalian cells
Clonality	Monoclonal
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	DF-6002, DF6002, DF6002
Background	Interleukin-12 subunit beta (IL12B/IL-12 p40) is a ~37 kDa protein. Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
References	1. Gutierrez E, et al. An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses. Med. 2023 May 12;4(5):326-340.e5. [HB769106]
Note	For research use only. Not suitable for clinical or therapeutic use.