Anti-Human IL-1Rrp2/IL-1R6 Reference Antibody (REGN6490, RUO) (HV045016)

Name: Anti-Human IL-1Rrp2/IL-1R6 Reference Antibody (REGN6490, RUO)
Brand: abinScience
SKU: HV045016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HV045016
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG4, kappa
Clone ID	REGN6490
Expression system	Mammalian cells
Clonality	Monoclonal
Target	IL1R-rp2, IL1RL2, IL1RRP2, IL-1Rrp2, IL-36 receptor, Interleukin-1 receptor-related protein 2, Interleukin-1 receptor-like 2, IL-36R
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9HB29
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	REGN6490
Background	Interleukin-1 receptor-like 2 (IL1RL2/IL-36R) is a ~65 kDa protein. Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
References	1. Jason E Hawkes, et al. The role of the interleukin-36 axis in generalized pustular psoriasis: a review of the mechanism of action of spesolimab. Front Immunol. 2023 Nov 21:14:1292941. [HV045016]
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human IL1RL2/IL-36R (REGN6490)

References

Datasheet

Anti-Human IL-1Rrp2/IL-1R6 Reference Antibody (REGN6490, RUO).pdf

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Anti-Human IL-1Rrp2/IL-1R6 Reference Antibody (REGN6490, RUO) (HV045016)

Overview

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References

Datasheet

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