Anti-Human MDM2 Reference Antibody (NMC-001, RUO) (HX174026)

Name: Anti-Human MDM2 Reference Antibody (NMC-001, RUO)
Brand: abinScience
SKU: HX174026
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HX174026
Description	Anti-Human MDM2 (NMC-001) (HX174026) is a research-grade recombinant antibody targeting MDM2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Clone ID	NMC-001
Expression system	Mammalian cells
Clonality	Monoclonal
Target	MDM2, Hdm2, p53-binding protein Mdm2, E3 ubiquitin-protein ligase Mdm2, RING-type E3 ubiquitin transferase Mdm2, Double minute 2 protein, Oncoprotein Mdm2
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q00987
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	NMC-001, NMC001, NMC001
Background	E3 ubiquitin-protein ligase Mdm2 is a ~55 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. 1. Liang, L. et al. (2018) Cell chemical biology 25, 761-774.e5. PMID: 29681526 2. Girnita, L. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 8247-52. PMID: 12821780 3. Li, M. et al. (2004) Molecular cell 13, 879-86. PMID: 15053880 4. Bernardi, R. et al. (2004) Nature cell biology 6, 665-72. PMID: 15195100 5. Brady, M. et al. (2005) Molecular and cellular biology 25, 545-53. PMID: 15632057 6. Sdek, P. et al. (2005) Molecular cell 20, 699-708. PMID: 16337594 7. Stevenson, LF. et al. (2007) The EMBO journal 26, 976-86. PMID: 17290220 8. Chen, D. et al. (2009) EMBO reports 10, 166-72. PMID: 19098711 9. Busso, CS. et al. (2009) Oncogene 28, 1616-25. PMID: 19219073 10. Li, DQ. et al. (2009) The Journal of biological chemistry 284, 34545-52. PMID: 19837670
Note	For research use only. Not suitable for clinical or therapeutic use.