Anti-Human beta-NGF Reference Antibody (MEDI 7352, RUO) (HF909086)

Name: Anti-Human beta-NGF Reference Antibody (MEDI 7352, RUO)
Brand: abinScience
SKU: HF909086
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HF909086
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	MEDI 7352
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Beta-nerve growth factor, NGFB, Beta-NGF, NGF
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P01138
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	MEDI-7352, MEDI7352, MEDI7352
Background	Beta-nerve growth factor (NGF/Beta-NGF) is a ~26 kDa protein. Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. 1. Einarsdottir, E. et al. (2004) Human molecular genetics 13, 799-805. PMID: 14976160 2. Carvalho, OP. et al. (2011) Journal of medical genetics 48, 131-5. PMID: 20978020 3. Wijeyewickrema, LC. et al. (2010) The Journal of biological chemistry 285, 11793-9. PMID: 20164177
References	1. Yu H, et al. Osteoarthritis pain[J]. International journal of molecular sciences, 2022, 23(9): 4642. [HF909086]
Note	For research use only. Not suitable for clinical or therapeutic use.