Anti-Human NONO Reference Antibody (PAT-LM1, RUO) (HS752016)

Name: Anti-Human NONO Reference Antibody (PAT-LM1, RUO)
Brand: abinScience
SKU: HS752016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HS752016
Description	Anti-Human NONO (PAT-LM1) (HS752016) is a research-grade recombinant antibody targeting 54 kDa nuclear RNA- and DNA-binding protein. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG
Clone ID	PAT-LM1
Expression system	Mammalian cells
Target	54 kDa nuclear RNA- and DNA-binding protein, NRB54, p54nrb, NMT55, NonO protein, p54(nrb), 55 kDa nuclear protein, NONO, DNA-binding p52/p100 complex, 52 kDa subunit, Non-POU domain-containing octamer-binding protein
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q15233
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	PAT-LM1, PATLM1, PATLM1
Background	Non-POU domain-containing octamer-binding protein (NONO) is a ~54 kDa protein. DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. 1. Zhang, Z. et al. (2001) Cell 106, 465-75. PMID: 11525732 2. Peng, R. et al. (2002) RNA (New York, N.Y.) 8, 1334-47. PMID: 12403470 3. Mircsof, D. et al. (2015) Nature neuroscience 18, 1731-6. PMID: 26571461 8. Morchikh, M. et al. (2017) Molecular cell 67, 387-399.e5. PMID: 28712728
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human NONO (PAT-LM1)

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Anti-Human NONO Reference Antibody (PAT-LM1, RUO).pdf

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Anti-Human NONO Reference Antibody (PAT-LM1, RUO) (HS752016)

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