Anti-Human DPPIV/CD26 Reference Antibody (Begelomab, RUO) (HB015016)

Name: Anti-Human DPPIV/CD26 Reference Antibody (Begelomab, RUO)
Brand: abinScience
SKU: HB015016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HB015016
Description	Begelomab (HB015016) is a research-grade recombinant antibody targeting CD26. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Mouse
Isotype	IgG2b-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	TP103, Dipeptidyl peptidase IV, ADABP, Dipeptidyl peptidase 4, CD26, DPP4, Dipeptidyl peptidase IV soluble form, Dipeptidyl peptidase IV membrane form, DPP IV, ADCP2, Adenosine deaminase complexing protein 2, ADCP-2, T-cell activation antigen CD26
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P27487
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BT5/9, SAND-26, 1403744-56-8
Background	Dipeptidyl peptidase 4 (CD26/DPP4) is a ~88 kDa protein. Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. 1. Ikushima, H. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 8439-44. PMID: 10900005 2. Durinx, C. et al. (2000) European journal of biochemistry 267, 5608-13. PMID: 10951221 3. Ginés, S. et al. (2002) The Biochemical journal 361, 203-9. PMID: 11772392 4. Ohnuma, K. et al. (2007) The Journal of biological chemistry 282, 10117-10131. PMID: 17287217 5. Aertgeerts, K. et al. (2004) Protein science : a publication of the Protein Society 13, 145-54. PMID: 14691230 9. Davoodi, J. et al. (2007) Proteomics 7, 2300-10. PMID: 17549790
Note	For research use only. Not suitable for clinical or therapeutic use.

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Datasheet

Anti-Human DPPIV/CD26 Reference Antibody (Begelomab, RUO).pdf

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Anti-Human DPPIV/CD26 Reference Antibody (Begelomab, RUO) (HB015016)

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