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Anti-Human SOST/Sclerostin Reference Antibody (Blosozumab, RUO) (HV185026)

Anti-Human SOST/Sclerostin Reference Antibody (Blosozumab, RUO)
Anti-Human SOST/Sclerostin Reference Antibody (Blosozumab, RUO)
Anti-Human SOST/Sclerostin Reference Antibody (Blosozumab, RUO)
Anti-Human SOST/Sclerostin Reference Antibody (Blosozumab, RUO)
Anti-Human SOST/Sclerostin Reference Antibody (Blosozumab, RUO)
Anti-Human SOST/Sclerostin Reference Antibody (Blosozumab, RUO)
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  • Overview

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Overview
Catalog No.HV185026
Description
Blosozumab (HV185026) is a research-grade recombinant antibody targeting SOST. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivityHuman
ApplicationsELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host speciesHuman
ClonalityMonoclonal
IsotypeIgG4-kappa
Expression system Mammalian cells
Target SOST, Sclerostin
Endotoxin level < 10 EU/mg
Purity >95% purity as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession Q9BQB4
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate NamesLY2541546, 1132758-87-2
Background

Sclerostin (SOST) is a ~24 kDa protein. Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

Note For research use only. Not suitable for clinical or therapeutic use.
Isotype Control Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)
Images
  • Anti-Human SOST/Sclerostin Reference Antibody (Blosozumab, RUO)

    SEC-HPLC

    SEC-HPLC detection for Research Grade Blosozumab.

  • Anti-Human SOST/Sclerostin Reference Antibody (Blosozumab, RUO)

    Bioactivity

    Detects Human SOST in indirect ELISAs.

  • Anti-Human SOST/Sclerostin Reference Antibody (Blosozumab, RUO)

    SDS-PAGE

    SDS-PAGE for Research Grade Blosozumab

References
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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