Anti-Human ANGPTL4 Reference Antibody (Corveldebart, RUO) (HV344016)

Name: Anti-Human ANGPTL4 Reference Antibody (Corveldebart, RUO)
Brand: abinScience
SKU: HV344016
Price: 370 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HV344016

Description

Research Grade corveldebart (HV344016) is a human monoclonal antibody. Suitable for Human.

Species reactivity

Human

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Endotoxin level

< 10 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9BY76

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Angiopoietin-related protein 4 (ANGPTL4) is a ~45 kDa protein. Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis.

1. Yin, W. et al. (2009) The Journal of biological chemistry 284, 13213-22. PMID: 19270337

2. Lei, X. et al. (2011) The Journal of biological chemistry 286, 15747-56. PMID: 21398697

3. Mysling, S. et al. (2016) eLife 5. PMID: 27929370

4. Kristensen, KK. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E6020-E6029. PMID: 29899144

5. Ito, Y. et al. (2003) Cancer research 63, 6651-7. PMID: 14583458

6. Cazes, A. et al. (2006) Circulation research 99, 1207-15. PMID: 17068295

Note

For research use only.

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References

Datasheet