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Anti-Human CD8 alpha Reference Antibody (Crefmirlimab, RUO) (HP158016)

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Anti-Human CD8 alpha Reference Antibody (Crefmirlimab, RUO)

Anti-Human CD8 alpha Reference Antibody (Crefmirlimab, RUO)

Anti-Human CD8 alpha Reference Antibody (Crefmirlimab, RUO)

Anti-Human CD8 alpha Reference Antibody (Crefmirlimab, RUO)

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Spec:

100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.	HP158016
Description	Crefmirlimab (HP158016) is a research-grade recombinant antibody targeting CD8. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	(scFv-kappa-heavy) -h- CH3
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	T-cell surface glycoprotein CD8 alpha chain, CD8a, T-lymphocyte differentiation antigen T8/Leu-2, MAL, CD8A
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Purified by ion exchange chromatography.
Accession	P01732
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	89Zr-IAB22M2C, IAB22M2C, 89Zr-Df-IAB22M2C, 2611099-93-3
Background	T-cell surface glycoprotein CD8 alpha chain (CD8A) is a ~25 kDa protein. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

Detects CD8A in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Crefmirlimab.

References

Datasheet

Anti-Human CD8 alpha Reference Antibody (Crefmirlimab, RUO).pdf

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Formula

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Anti-Human CD8 alpha Reference Antibody (Crefmirlimab, RUO)