Anti-Human Claudin-1 Reference Antibody (Eclutatug, RUO) (HF976036)

Name: Anti-Human Claudin-1 Reference Antibody (Eclutatug, RUO)
Brand: abinScience
SKU: HF976036
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HF976036
Description	eclutatug (HF976036) is a research-grade recombinant antibody targeting CLDN1/Claudin-1. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1, Kappa
Species	Human
Clonality	Monoclonal
Target	CLDN1/Claudin-1
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Accession	O95832
Form	Liquid
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2922054-25-7
Background	Claudin-1 (CLDN1) is a ~22 kDa protein. Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. 1. Kirschner, N. et al. (2013) The Journal of investigative dermatology 133, 1161-9. PMID: 23407391
Note	For research use only. Not suitable for clinical or therapeutic use.