Anti-Human Serpin A1/ alpha 1‑Antitrypsin Reference Antibody (Efdoralprin Alfa, RUO) (HF638026)

Name: Anti-Human Serpin A1/ alpha 1‑Antitrypsin Reference Antibody (Efdoralprin Alfa, RUO)
Brand: abinScience
SKU: HF638026
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HF638026
Description	efdoralprin alfa (HF638026) is a research-grade recombinant antibody targeting Bone marrow serine protease. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
Species	Human
Clonality	Monoclonal
Target	Bone marrow serine protease, EC:3.4.21.37, ELA2, ELANE, Elastase-2, HLE, Human leukocyte elastase, Medullasin, Neutrophil elastase, PMN elastase
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P08246
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CAS: 2539844-42-1
Background	Neutrophil elastase (AAT) is a ~28 kDa protein. Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Promotes blood coagulation. Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG). 1. Tralau, T. et al. (2004) Experimental dermatology 13, 316-25. PMID: 15140022 2. Oltra, SS. et al. (2023) Cell death and differentiation 30, 1366-1381. PMID: 36899106 3. Massberg, S. et al. (2010) Nature medicine 16, 887-96. PMID: 20676107 4. Waisberg, M. et al. (2014) PLoS pathogens 10, e1004338. PMID: 25211214 5. Si-Tahar, M. et al. (1997) The Journal of biological chemistry 272, 11636-47. PMID: 9111081 6. Belaaouaj, A. et al. (2000) Science (New York, N.Y.) 289, 1185-8. PMID: 10947984
Note	For research use only. Not suitable for clinical or therapeutic use.

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Anti-Human Serpin A1/ alpha 1‑Antitrypsin Reference Antibody (Efdoralprin Alfa, RUO).pdf

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Anti-Human Serpin A1/ alpha 1‑Antitrypsin Reference Antibody (Efdoralprin Alfa, RUO) (HF638026)

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Datasheet

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