Research Grade Eftozanermin Alfa (HT348136)

Name: Research Grade Eftozanermin Alfa
Brand: abinScience
SKU: HT348136
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HT348136
Description	Eftozanermin Alfa (HT348136) is a research-grade recombinant antibody targeting CD262. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
Isotype	Fusion - [Homo sapiens TNFSF10 (TNF superfamily member 10, tumor necrosis factor (ligand) superfamily, member 10)]2 - Homo sapiens IGHG1 Fc (Fragment constant)
Expression system	Mammalian cells
Target	TRAILR2, TRAIL-R2, Death receptor 5, CD262, DR5, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9, TRAIL receptor 2, TRICK2, TNFRSF10B, KILLER, TNF-related apoptosis-inducing ligand receptor 2
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O14763
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ABBV-621, PR-1625011, 1820660-69-2
Background	Tumor necrosis factor receptor superfamily member 10B (CD262/TRAIL-R2) is a ~47 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. 1. Hymowitz, SG. et al. (1999) Molecular cell 4, 563-71. PMID: 10549288
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects CD262/TNFRSF10B/TRAIL-R2/DR5 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Eftozanermin Alfa

References

Datasheet

Research Grade Eftozanermin Alfa.pdf

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Research Grade Eftozanermin Alfa (HT348136)

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