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Research Grade elipunercept (HB070076)

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Overview

Catalog No.	HB070076
Description	elipunercept (HB070076) is a research-grade recombinant antibody targeting TNFa/TNF-alpha. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Applications	Functional assay
Isotype	TNFRSF1B-Fc
Clonality	Monoclonal
Target	TNFa/TNF-alpha
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE
Purification	Protein A/G purified from cell culture supernatant.
Accession	P01375
Form	Liquid
Storage buffer	0.01 M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternate Names	CAS: 3037408-21-9
Background	Tumor necrosis factor is a ~25 kDa protein. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. 1. Nie, H. et al. (2013) Nature medicine 19, 322-8. PMID: 23396208 2. Friedmann, E. et al. (2006) Nature cell biology 8, 843-8. PMID: 16829952 3. Jinesh G, G. et al. (2012) Journal of leukocyte biology 92, 233-44. PMID: 22517918 4. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819
Note	For research use only.

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Datasheet

Research Grade elipunercept.pdf

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Research Grade elipunercept