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Anti-HCMV gB Reference Antibody (Fiztasovimab, RUO) (VK665026)

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Anti-HCMV gB Reference Antibody (Fiztasovimab, RUO)

Anti-HCMV gB Reference Antibody (Fiztasovimab, RUO)

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.	VK665026
Description	Fiztasovimab (VK665026) is a research-grade recombinant antibody targeting Envelope glycoprotein B. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1, lambda2
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Envelope glycoprotein B, gB, UL55
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P06473
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	NPC21, NPC-21, NPC21, 2467411-25-0
Background	Envelope glycoprotein B (gB) is a ~102 kDa protein. Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. May be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Interacts with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Also participates in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for Research Grade Fiztasovimab.

References

Datasheet

Anti-HCMV gB Reference Antibody (Fiztasovimab, RUO).pdf

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Formula

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Anti-HCMV gB Reference Antibody (Fiztasovimab, RUO)