Anti-Human HTRA1/PRSS11 Reference Antibody (Galegenimab, RUO) (HV033016)

Name: Anti-Human HTRA1/PRSS11 Reference Antibody (Galegenimab, RUO)
Brand: abinScience
SKU: HV033016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HV033016
Description	Galegenimab (HV033016) is a research-grade recombinant antibody targeting High-temperature requirement A serine peptidase 1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG2-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	High-temperature requirement A serine peptidase 1, Serine protease 11, HTRA1, PRSS11, HTRA, Serine protease HTRA1, L56
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q92743
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	FHTR2163, RG-6147, RG6417, RO-7171009, RO71710092403683-24-7
Background	Serine protease HTRA1 (PRSS11) is a ~51 kDa protein. Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins.
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

SEC-HPLC detection for Research Grade Galegenimab.
SDS-PAGE

SDS-PAGE for Research Grade Galegenimab

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Datasheet

Anti-Human HTRA1/PRSS11 Reference Antibody (Galegenimab, RUO).pdf

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Anti-Human HTRA1/PRSS11 Reference Antibody (Galegenimab, RUO) (HV033016)

Overview

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References

Datasheet

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