Anti-Human CD221/IGF1R & ErbB3/Her3 Bispecific Reference Antibody (Istiratumab, RUO) (HY353076)

Name: Anti-Human CD221/IGF1R & ErbB3/Her3 Bispecific Reference Antibody (Istiratumab, RUO)
Brand: abinScience
SKU: HY353076
Price: 320 USD
Availability: InStock

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Overview

Catalog No.	HY353076
Description	Istiratumab (HY353076) is a research-grade recombinant antibody targeting CD221. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa-[scFv]2
Expression system	Mammalian cells
Clonality	Monoclonal
Target	CD221, Insulin-like growth factor 1 receptor, IGF1R, Insulin-like growth factor I receptor, IGF-I receptor, ERBB3, HER3, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, Receptor tyrosine-protein kinase erbB-3
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P08069 & P21860
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Bispecific, MM-005, MM-141, 1509928-04-4
Background	Istiratumab (M-6495) is bispecific monoclonal antibody targeting IGF-1R and ErbB3. Istiratumab induces IGF-1R and ErbB3 receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers.
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Istiratumab.
Flow CytoMetry

Flow-cytometry using anti-human ERBB3 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human ERBB3 monoclonal antibody (Catalog: HY353076) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.

References

Datasheet

Anti-Human CD221/IGF1R & ErbB3/Her3 Bispecific Reference Antibody (Istiratumab, RUO).pdf

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Recombinant Proteins

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Anti-Human CD221/IGF1R & ErbB3/Her3 Bispecific Reference Antibody (Istiratumab, RUO) (HY353076)

Overview

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References

Datasheet

SDS

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