Anti-Human KIR2DL2/CD158b11 Reference Antibody (Lacutamab, RUO) (HW633016)

Name: Anti-Human KIR2DL2/CD158b11 Reference Antibody (Lacutamab, RUO)
Brand: abinScience
SKU: HW633016
Price: 176 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.	HW633016
Description	Lacutamab (HW633016) is a research-grade recombinant antibody targeting CD158K. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	CD158K, MHC class I NK cell receptor, NKAT4, Natural killer-associated transcript 4, KIR3DL2, p70 NK receptor CL-5, CD158k, p70 natural killer cell receptor clone CL-5, CD158 antigen-like family member K, Killer cell immunoglobulin-like receptor 3DL2, NKAT-4
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P43630
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	IPH4102, 2187368-16-5
Background	Killer cell immunoglobulin-like receptor 3DL2 (CD158k/KIR3DL2) is a ~50 kDa protein. Receptor on natural killer (NK) cells and T cells for MHC class I molecules. Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions. Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity. 1. Goodridge, JP. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 3553-62. PMID: 24018270 2. Dulberger, CL. et al. (2017) Immunity 46, 1018-1029.e7. PMID: 28636952 3. Song, S. et al. (2016) Nature medicine 22, 397-403. PMID: 26928464
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for Research Grade Lacutamab.
Western blot

Western blot analysis was performed using anti-CD158k/KIR3DL2 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD158k/KIR3DL2 (Catalog No: HW633011)
Lane 2: negative control