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Anti-Human CCR5 Reference Antibody (Leronlimab, RUO) (HW412016)

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Anti-Human CCR5 Reference Antibody (Leronlimab, RUO)

Anti-Human CCR5 Reference Antibody (Leronlimab, RUO)

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100ug
1mg

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Overview

Catalog No.	HW412016
Description	Leronlimab (HW412016) is a research-grade recombinant antibody targeting CD195. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	IgG4-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	C-C CKR-5, CC-CKR-5, CMKBR5, HIV-1 fusion coreceptor, CHEMR13, CCR5, C-C chemokine receptor type 5, CD195, CCR-5
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P51681
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	HuPRO-140, PA-14, PRO-140, 674782-26-4
Background	C-C chemokine receptor type 5 (CD195/CCR5) is a ~40 kDa protein. Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. 1. Sharapova, TN. et al. (2018) Acta naturae 10, 115-120. PMID: 30713770
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Leronlimab.

References

Datasheet

Anti-Human CCR5 Reference Antibody (Leronlimab, RUO).pdf

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Anti-Human CCR5 Reference Antibody (Leronlimab, RUO)