Anti-Human APP/Protease Nexin II (Amyloid beta) Reference Antibody (Merinetug, RUO) (HY235296)

Name: Anti-Human APP/Protease Nexin II (Amyloid beta) Reference Antibody (Merinetug, RUO)
Brand: abinScience
SKU: HY235296
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HY235296
Description	merinetug (HY235296) is a research-grade recombinant antibody targeting APP/Amyloid beta. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, FACS, Functional assay
Host species	Human
Isotype	IgG1, kappa
Target	APP/Amyloid beta
Purity	>95% as determined by SDS-PAGE
Accession	P05067
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CAS: 3024381-10-7
Background	Amyloid-beta precursor protein is a ~86 kDa protein. Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. 1. Baumkötter, F. et al. (2014) The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 11159-72. PMID: 25122912 2. Satpute-Krishnan, P. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 16532-7. PMID: 17062754 3. Seamster, PE. et al. (2012) Physical biology 9, 055005. PMID: 23011729
Note	For research use only.