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Anti-Human IL1RAP Reference Antibody (Nadunolimab, RUO) (HV556016)

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Anti-Human IL1RAP Reference Antibody (Nadunolimab, RUO)

Anti-Human IL1RAP Reference Antibody (Nadunolimab, RUO)

Anti-Human IL1RAP Reference Antibody (Nadunolimab, RUO)

Anti-Human IL1RAP Reference Antibody (Nadunolimab, RUO)

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Spec:

100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.	HV556016
Description	Nadunolimab (HV556016) is a research-grade recombinant antibody targeting IL-1R3. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	IgG1-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	IL-1R3, C3orf13, Interleukin-1 receptor 3, Interleukin-1 receptor accessory protein, IL1RAP, IL-1R-3, IL-1 receptor accessory protein, IL1R3, IL-1RAcP
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9NPH3
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CAN-04, CAN04, Nidanilimab, 2171061-85-9
Background	Interleukin-1 receptor accessory protein (IL1RAP) is a ~65 kDa protein. Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex.
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

SEC-HPLC detection for Research Grade Nadunolimab.
SDS-PAGE

SDS-PAGE for Research Grade Nadunolimab.

References

Datasheet

Anti-Human IL1RAP Reference Antibody (Nadunolimab, RUO).pdf

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Formula

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Anti-Human IL1RAP Reference Antibody (Nadunolimab, RUO)