Anti-Human MASP2 Reference Antibody (Narsoplimab, RUO) (HT020016)

Name: Anti-Human MASP2 Reference Antibody (Narsoplimab, RUO)
Brand: abinScience
SKU: HT020016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HT020016
Description	Narsoplimab (HT020016) is a research-grade recombinant antibody targeting Mannan-binding lectin serine protease 2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG4-lambda
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Mannan-binding lectin serine protease 2, Mannose-binding protein-associated serine protease 2, MASP-2, MBL-associated serine protease 2, MASP2
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O00187
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	OMS721, 2108782-45-0
Background	Mannan-binding lectin serine protease 2 (MASP2) is a ~75 kDa protein. Precursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. MASP2 is cleaved and activated by MASP1 in response to lectin-binding to pathogen carbohydrates. Can activate prothrombin to thrombin. 1. Rossi, V. et al. (2001) The Journal of biological chemistry 276, 40880-7. PMID: 11527969 2. Héja, D. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 10498-503. PMID: 22691502 3. Degn, SE. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 3957-69. PMID: 22966085 4. Matsushita, M. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 165, 2637-42. PMID: 10946292 5. Kidmose, RT. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 15425-30. PMID: 22949645 6. Thiel, S. et al. (1997) Nature 386, 506-10. PMID: 9087411 7. Valenzuela Leon, PC. et al. (2025) Journal of medicinal chemistry 68, 4663-4671. PMID: 39924859
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects Human MASP2 in indirect ELISAs.
Bioactivity

SEC-HPLC detection for Research Grade Narsoplimab.
SDS-PAGE

SDS-PAGE for Research Grade Narsoplimab.

References

Datasheet

Anti-Human MASP2 Reference Antibody (Narsoplimab, RUO).pdf

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Anti-Human MASP2 Reference Antibody (Narsoplimab, RUO) (HT020016)

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