Anti-Human MAdCAM-1 Reference Antibody (Ontamalimab, RUO) (HC589016)

Name: Anti-Human MAdCAM-1 Reference Antibody (Ontamalimab, RUO)
Brand: abinScience
SKU: HC589016
Price: 176 USD
Availability: InStock

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SDS

Overview

Catalog No.	HC589016
Description	Ontamalimab (HC589016) is a research-grade recombinant antibody targeting MAdCAM-1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG2-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	MAdCAM-1, hMAdCAM-1, MADCAM1, Mucosal addressin cell adhesion molecule 1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q13477
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	PF-00547659, PF-547659, SHP647, 2098790-40-8
Background	Mucosal addressin cell adhesion molecule 1 (MADCAM1) is a ~40 kDa protein. Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Note	For research use only. Not suitable for clinical or therapeutic use.

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SEC-HPLC

SEC-HPLC detection for Research Grade Ontamalimab.
Bioactivity

Detects MADCAM1 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Ontamalimab.

References

Datasheet

Anti-Human MAdCAM-1 Reference Antibody (Ontamalimab, RUO).pdf

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Recombinant Proteins

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Anti-Human MAdCAM-1 Reference Antibody (Ontamalimab, RUO) (HC589016)

Overview

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References

Datasheet

SDS

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