Anti-Human Nogo Reference Antibody (Ozanezumab, RUO) (HP021016)

Name: Anti-Human Nogo Reference Antibody (Ozanezumab, RUO)
Brand: abinScience
SKU: HP021016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HP021016
Description	Ozanezumab (HP021016) is a research-grade recombinant antibody targeting RTN-x. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-nd
Expression system	Mammalian cells
Clonality	Monoclonal
Target	RTN-x, Reticulon-4, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, NOGO, Nogo protein, Neurite outgrowth inhibitor, NSP, Reticulon-5, KIAA0886, RTN4, Foocen
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9NQC3
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	GSK-1223249, 1310680-64-8
Background	Reticulon-4 (RTN4) is a ~129 kDa protein. Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). 1. Yamamoto, Y. et al. (2014) The Biochemical journal 458, 69-79. PMID: 24262037 2. Urade, T. et al. (2014) The Kobe journal of medical sciences 60, E57-65. PMID: 25612671 3. Wang, S. et al. (2016) eLife 5. PMID: 27619977 4. Rämö, O. et al. (2016) Scientific reports 6, 35969. PMID: 27786289 5. Christodoulou, A. et al. (2016) Journal of cell science 129, 1552-65. PMID: 26906412
Note	For research use only. Not suitable for clinical or therapeutic use.