Anti-Human Semaphorin 4D/CD100 Reference Antibody (Pepinemab, RUO) (HV563016)

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100ug
1mg

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Overview

Catalog No.	HV563016
Description	Pepinemab (HV563016) is a research-grade recombinant antibody targeting CD100. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	IgG4-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	A8, Semaphorin-4D, GR3, BB18, SEMAJ, C9orf164, CD100, SEMA4D
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q92854
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	VX-15, VX15/2503, 2097151-87-4
Background	Semaphorin-4D (CD100/SEMA4D) is a ~96 kDa protein. Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner. Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. 1. Janssen, BJ. et al. (2010) Nature 467, 1118-22. PMID: 20877282 2. Vodrazka, P. et al. (2009) The European journal of neuroscience 30, 1193-208. PMID: 19788569 3. Basile, JR. et al. (2005) Molecular and cellular biology 25, 6889-98. PMID: 16055703 4. Hall, KT. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 11780-5. PMID: 8876214
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects CD100/SEMA4D in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Pepinemab.

References

Datasheet

Anti-Human Semaphorin 4D/CD100 Reference Antibody (Pepinemab, RUO).pdf

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Formula

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Recombinant Proteins

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Anti-Human Semaphorin 4D/CD100 Reference Antibody (Pepinemab, RUO) (HV563016)

Overview

Images

References

Datasheet

SDS

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