Anti-Human CD274/PD-L1/B7-H1 & PD-1 Bispecific Reference Antibody (Reozalimab, RUO) (HV974216)

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100ug
1mg

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Overview

Catalog No.	HV974216
Description	Reozalimab (HV974216) is a research-grade recombinant antibody targeting CD1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	Ig(G1-kappa_G1-lambda2)
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	B7-H1, Programmed cell death 1 ligand 1, PDCD1 ligand 1, PDCD1L1, B7 homolog 1, PDCD1LG1, PDL1, hPD-L1, Programmed death ligand 1, B7H1, PD-L1, CD274, Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9NZQ7 & Q15116
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Bispecific, IBI318, IBI-318, IBI318, 2445259-99-2
Background	Reozalimab is a bispecific antibody targeting to PD-1/PD-L1. Reozalimab mediates antibody-dependent cell cytotoxicity in cancer research.
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects PDL1 in indirect ELISA.
Bioactivity

Detects recombinant human PD1 (Cat No.: HS870021) in indirect ELISA.
Flow CytoMetry

Flow-cytometry using anti-human CD274 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human CD274 monoclonal antibody (Catalog: HV974216) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
Western blot

Western blot analysis was performed using anti-CD274/PD-L1/B7-H1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD274/PD-L1/B7-H1 (Catalog No: HV974011)
Lane 2: negative control

References

Datasheet

Anti-Human CD274/PD-L1/B7-H1 & PD-1 Bispecific Reference Antibody (Reozalimab, RUO).pdf

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Recombinant Proteins

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Anti-Human CD274/PD-L1/B7-H1 & PD-1 Bispecific Reference Antibody (Reozalimab, RUO) (HV974216)

Overview

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References

Datasheet

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