Research Grade Samrotamab (HV777016)

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100ug
1mg

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Overview

Catalog No.	HV777016
Description	Samrotamab (HV777016) is a research-grade recombinant antibody targeting Leucine-rich repeat protein induced by beta-amyloid homolog. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	IgG1-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Leucine-rich repeat protein induced by beta-amyloid homolog, LRRC15, Leucine-rich repeat-containing protein 15, LIB, hLib
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q8TF66
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	ABBV-085, PR-1498487-MMAE, PR-1498487, Samrotamabvedotin, 2052591-32-7
Background	Leucine-rich repeat-containing protein 15 (LRRC15/LIB) is a ~64 kDa protein. (Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein. Does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes in trans SARS-CoV-2 infection of ACE2(+) cells when expressed on nearby cells. 1. Song, J. et al. (2022) PLoS biology 20, e3001805. PMID: 36228039 2. Shilts, J. et al. (2023) PLoS biology 21, e3001959. PMID: 36735681 3. Loo, L. et al. (2023) PLoS biology 21, e3001967. PMID: 36757924
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

SEC-HPLC detection for Research Grade Samrotamab.
SDS-PAGE

SDS-PAGE for Research Grade Samrotamab

References

Datasheet

Research Grade Samrotamab.pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Research Grade Samrotamab (HV777016)

Overview

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References

Datasheet

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