Anti-HCMV HCMV gH Reference Antibody (Sevirumab, RUO) (VK705016)

Name: Anti-HCMV HCMV gH Reference Antibody (Sevirumab, RUO)
Brand: abinScience
SKU: VK705016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	VK705016
Description	Sevirumab (VK705016) is a research-grade recombinant antibody targeting Envelope glycoprotein H. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG1, kappa
Expression system	Mammalian cells
Target	Envelope glycoprotein H, gH, gH, UL75
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P12824
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EV27, MSL109, SDZMSL109, 138660-96-5
Background	Envelope glycoprotein H (gHUL75) is a ~84 kDa protein. The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. In human cytomegalovirus, forms two distinct complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope. The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA, and in glioblastoma cells by interacting with host EPHA2.
Note	For research use only. Not suitable for clinical or therapeutic use.