Anti-Human TRAIL R2/TNFRSF10B Reference Antibody (Zaptuzumab, RUO) (HT348156)

Name: Anti-Human TRAIL R2/TNFRSF10B Reference Antibody (Zaptuzumab, RUO)
Brand: abinScience
SKU: HT348156
Price: 176 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HT348156

Description

Zaptuzumab (HT348156) is a research-grade recombinant antibody targeting CD262.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.

Species reactivity

Human

Applications

ELISA, FACS, Functional assay

Host species

Human

Clonality

Monoclonal

Target

CD262, DR5, Death receptor 5, KILLER, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAIL-R2, TRAILR2, TRICK2, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9

Endotoxin level

< 10 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O14763

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Tumor necrosis factor receptor superfamily member 10B (DR5) is a ~47 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

1. Hymowitz, SG. et al. (1999) Molecular cell 4, 563-71. PMID: 10549288

Note

For research use only.

Images

References

Datasheet

Anti-Human TRAIL R2/TNFRSF10B Reference Antibody (Zaptuzumab, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human TRAIL R2/TNFRSF10B Reference Antibody (Zaptuzumab, RUO) (HT348156)

Overview

Images

References

Datasheet

SDS

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