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Anti-Human EMMPRIN/CD147 Reference Antibody (Ziralimumab, RUO) (HW664026)

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Anti-Human EMMPRIN/CD147 Reference Antibody (Ziralimumab, RUO)

Anti-Human EMMPRIN/CD147 Reference Antibody (Ziralimumab, RUO)

Anti-Human EMMPRIN/CD147 Reference Antibody (Ziralimumab, RUO)

Anti-Human EMMPRIN/CD147 Reference Antibody (Ziralimumab, RUO)

Anti-Human EMMPRIN/CD147 Reference Antibody (Ziralimumab, RUO)

Anti-Human EMMPRIN/CD147 Reference Antibody (Ziralimumab, RUO)

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Spec:

100ug
1mg

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References
Datasheet
SDS

Overview

Catalog No.	HW664026
Description	Ziralimumab (HW664026) is a research-grade recombinant antibody targeting CD147. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgM-nd
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Hepatoma-associated antigen, BSG, HAb18G, 5F7, TCSF, OK blood group antigen, Collagenase stimulatory factor, CD147, Leukocyte activation antigen M6, Basigin, Extracellular matrix metalloproteinase inducer, EMMPRIN, Tumor cell-derived collagenase stimulatory factor
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein L purified from cell culture supernatant.
Accession	P35613
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	ABX-RB2, 1427008-29-4, cem2.6
Background	Basigin (CD147/BSG) is a ~42 kDa protein. Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes. 1. Aït-Ali, N. et al. (2015) Cell 161, 817-32. PMID: 25957687 2. Redzic, JS. et al. (2011) Journal of molecular biology 411, 68-82. PMID: 21620857
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Western blot

Western blot analysis was performed using anti-CD147/BSG monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD147/BSG (Catalog No: HW664011)
Lane 2: negative control
Bioactivity

Detects recombinant CD147 (Catalog No: HW664011) in indirect ELISA.
SDS-PAGE

SDS-PAGE for Research Grade Ziralimumab

References

Datasheet

Anti-Human EMMPRIN/CD147 Reference Antibody (Ziralimumab, RUO).pdf

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Anti-Human EMMPRIN/CD147 Reference Antibody (Ziralimumab, RUO)