Lymphocytic Choriomeningitis Virus (LCMV) Research Reagents — Antibodies & Recombinant Proteins

Glycoprotein Complex (GPC / GP1 / GP2)
GPC is synthesized as a precursor cleaved by SKI-1/S1P into GP1 (receptor binding via α-dystroglycan) and GP2 (class I fusion subunit). GP1 is the primary target for neutralizing antibodies, and GP-specific CD8+ T cell responses are critical for LCMV clearance. abinScience offers the most complete LCMV glycoprotein set available:
• Full-length GPC complex: C-Fc (VK012021) and C-Fc variant (VK012031)
• GP1 subunit: C-Fc (VK012041), N-His (VK012042), and C-Fc variant (VK012051)
• GP2 subunit: N-His (VK012062)
• Detection antibodies: anti-GP1 pAb (VK012044) and anti-GP2 pAb (VK012064)

Nucleoprotein (NP)
NP is the most abundant viral protein and the primary immunodominant CD8+ T cell antigen in LCMV infection — the GP33 and NP396 epitopes are among the best-characterized viral CD8+ T cell epitopes in immunology. NP is also the standard diagnostic antigen for LCMV serology in rodent colony health monitoring. Available: recombinant NP protein N-His (VK012012) and anti-NP polyclonal antibody (VK012014).

RdRp / L Protein (RNA Polymerase)
The L protein is the RNA-dependent RNA polymerase and a target for broad-spectrum arenavirus antivirals (ribavirin, favipiravir). Available: recombinant L protein fragment N-His-SUMO (VK147012) and anti-L polyclonal antibody (VK147014).

Which LCMV proteins are most important for T cell immunology research?
NP and GP1 contain the immunodominant CD8+ T cell epitopes: NP396–404 (H-2Db restricted) and GP33–41/GP276–286 (H-2Db/H-2Kb restricted) are the most extensively studied viral T cell epitopes in C57BL/6 mice. Our NP protein (VK012012) and GP1 protein (VK012041) can be used for antigen restimulation assays, ELISPOT, and flow cytometry-based T cell functional studies.

Do you have strain-specific reagents for LCMV Armstrong vs. clone 13?
LCMV Armstrong (acute clearance model) and clone 13 (chronic infection/T cell exhaustion model) differ primarily in GP1 (single amino acid change at position 260). Our current GP1 proteins are based on the Armstrong sequence. Contact us for clone 13-specific GP1 variants or custom protein production from your specific LCMV isolate.

Can these reagents be used for rodent colony LCMV screening?
Yes. LCMV is a common contaminant of rodent colonies and transplantable tumor cell lines. Our NP protein (VK012012) is suitable as an ELISA coating antigen for serological screening of mouse and hamster colonies, and the anti-NP pAb (VK012014) enables immunofluorescence or IHC detection of LCMV-infected cells.

Explore reagents for related arenaviruses:

LCMV ✓ Lassa (LASV) Junin (JUNV) / Machupo (MACV) Lujo (LUJV)