All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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Antibodies (727)
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IFNA1/Interferon alpha-D (1)

AFP/Alpha-fetoprotein (1)

iga/IgA1 protease (1)

VTCN1/B7-H4 (1)

Envelopeglycoprotein E2/gp55 (2)

CD96 (2)

BMP10 (1)

NP/Nucleoprotein (3)

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IFNB1/IFN-beta (1)

CD132/IL2RG (1)

gp125 (1)

CD3 (1)

H3L (2)

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STEAP1 (1)

CXCL2/GRO-beta/MIP2-alpha (1)

TSHR/LGR3 (2)

D8L (2)

Ly6g/Ly-6G.1 (2)

GDF2/BMP9 (1)

Intermediate capsid protein VP6 (1)

CD222/IGF2R (1)

BDNF (1)

CD8a/Lyt2 (3)

p67 (1)

CD16/CD32 (1)

Tityustoxin VII/Toxin VII/Ts7 (1)

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S/Spike glycoprotein (2)

Hepacivirin/NS3P/Viroporin p70 (3)

Capsid protein VP2 (2)

Capsid protein VP3 (1)

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B6R (2)

IL6 (1)

PDGFD (1)

SplB (1)

long-chain α-neurotoxins (1)

E-DII (1)

CD20/MS4A1 (1)

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CCL24/Eotaxin-2/MPIF-2 (1)

VWF (1)

IFNAR1 (1)

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GP1 (2)

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Fusion glycoprotein/F Trimer (1)

A29L (2)

FOLH1/PSMA (1)

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env/Env polyprotein (4)

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TSG101 (2)

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EPO (1)

env/Envpolyprotein (1)

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mature virion in complex (5)

ROBO2 (1)

IL17A (4)

CD205/LY75/DEC-205 (1)

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long-chain neurotoxin (1)

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RHDV VP60 (1)

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G9&A16 complex (2)

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stxB/SLT-1b/VT1 (2)

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Dupilumab (2)

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env/Envelope protein (1)

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Spike glycoprotein 2 (5)

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gp46 (2)

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botA/BOTOX (1)

CD268/TNFRSF13C (2)

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protruding (P) domain (1)

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Spike (5)

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L1R/Protein L1 (4)

lukF (1)

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Virionprotein 1/2/3 (1)

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Capsid protein VP25 (2)

LRP6 (1)

HSV- gB (1)

IL18/IL1F4 (1)

IL11RA (1)

Mature virion in Complex [(VP0/1/3)5]12 (2)

CD49d/ITGA4 (1)

IL17F (1)

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Major capsid protein L1 (11)

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Spike glycoprotein (1)

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IL12B/IL-12 p40 (1)

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Capsid protein VP 1/2/3 (2)

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CD337/NCR3/NKp30 (1)

gp120/Glycoprotein 120 (1)

RSPO3 (1)

GDF15/MIC1 (1)

CD120b/TNFR2 (1)

shiga toxin type 2A/stx2A (1)

ProteinUL128 & UL131A (1)

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botA/BoNT (2)

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P domain (4)

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short-chain neurotoxin (1)

RBD (S6P trimer) (3)

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IL10 (1)

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gp120 (2)

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DKK1 (2)

IL22 (1)

APOE (1)

RBP2b (1)

p21/Mature core protein (1)

IL31 (4)

Pvs25 (1)

E1 & E2 (gp35 & gp70) (3)

IL38/IL1F10 (2)

VSIG4/CRIg (1)

BLLF1/MA/GP350 (1)

gp140/Env Trimer (2)

CD226/DNAM-1 (1)

A35R (5)

shiga toxin type 2/stx2B (1)

SSTR2/SRIF-1 (1)

GP/Glycoprotein (5)

LRRC15/LIB (1)

CD84 (1)

CSF1/M-CSF (1)

CD37/TSPAN26 (2)

C1S (1)

GDF11/BMP11 (1)

CD62L/SELL (1)

BAG3 (1)

gH/Envelope glycoprotein H (1)

FedF (1)

Outer capsid glycoprotein VP7 (1)

L3/CP-H/Protein II (1)

CSF2/GM-CSF (1)

Glycoprotein C/Gc (4)

ERVW-1/HERV-W-Env (1)

OPN/SPP1 (1)

IGF1 (1)

PDGFC (1)

Fusion glycoprotein F0 (5)

IL8/CXCL8 (1)

F/fusion protein (2)

IL9 (1)

F8/Coagulation factor VIII (4)

Fusion Protein (1)

GPC (18)

Heparanase (1)

wlaB/pglK (1)

ADAMTS5 (2)

IL13 (1)

CD319/SLAMF7 (1)

CDH1/CDH11 (1)

FGF21 (1)

CXCL9/MIG (1)

GREM1/DAND2 (1)

gp32/gp35/Envelope glycoprotein E1 (1)

ROBO4 (1)

ALPP/PLAP (1)

MERS-CoV RBD (1)

Protein prM/prM (3)

F12/Coagulationfactor XII (1)

A27L (5)

CFD (1)

Capsid protein (13)

G/Major surface glycoprotein G (2)

THPO/Thrombopoietin (1)

DPEP3 (1)

CLDN3/Claudin-3 (1)

IL31RA (1)

H3L/Ag35 (2)

TNFa/TNF-alpha (1)

TSLP (1)

L1/Major capsid protein L1 (2)

gE/Envelope glycoprotein E (1)

IGF2 (1)

Neuropeptide Y/NPY (1)

Major surface glycoprotein G (3)

CD100/SEMA4D (3)

NS1/Non-structural protein 1 (1)

CD254/RANKL/TNFSF11 (1)

CD127/IL7R (1)

E8L (2)

S1 N-terminal domain/S1-NTD (3)

SAA (1)

APP/Amyloid beta (1)

IL17C (1)

NGF/Beta-NGF (2)

IL23A (1)

ssRNA & Genome polyprotein (2)

GPRC5D (1)

EDE1 (1)

IL21 (1)

CCL8/MCP-2 (1)

Beta-toxin Cl13/Cb3 (3)

SERPINE1/PAI-1 (1)

Glycoprotein G (17)

Envelope glycoprotein GP350 (1)

Fc Block (1)

Prefusion Protein (2)

HGF (1)

Toxin B/tcdB (2)

ARG1/Arginase-1 (2)

IL11 (1)

BMP2 (2)

ADM/Adrenomedullin (1)

MUC16/CA-125 (1)

CD21/CR2 (1)

Alpha-toxin/hly (3)

CD73/NT5E (2)

CD228/MELTF (1)

CSF3/G-CSF (1)

PTP4A1/PRL1 (1)

BMP6 (1)

ENT2/SLC29A2 (1)

ANGPTL3 (1)

F2/Prothrombin/PIVKA-II (1)

shiga toxin type 1B/stx1B (2)

PSCA (1)

CD274/PD-L1 (2)

GFRAL (1)

MSLN/Mesothelin (1)

FAP/FAPalpha (1)

SOD1 (1)

gH/BXLF2 (2)

MUC5AC (1)

APCS/PTX2 (1)

IL5 (1)

IL20 (1)

Fusion glycoprotein (3)

IL1B/IL1F2 (1)

CD52 (1)

CCL17/TARC (1)

Procapsid [(VP0/1/3) 5] 12 (2)

tetX/Tetanus toxin (1)

aPC/Activated protein C (3)

Capsid (1)

IL2 (1)

pro-MSTN/GDF8 (1)

Toxin A/tcdA (2)

IL36RN/IL-1F5/IL-36Ra (1)

Pre-F/Fusion glycoprotein F0 (2)

GP1 glycoprotein (2)

Hemagglutinin (1)

Spike glycoprotein E2 (1)

fimH (1)
Species

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Human papillomavirus 59 (HPV59) (1)

Puumala virus (PUUV) (2)

Sudan ebolavirus (SEBOV) (1)

Coxsackievirus A16 (CVA16) (2)

Monkey (1)

Human hepatitis A virus (HHAV) (1)

Japanese encephalitis virus (JEV) (1)

Dengue virus type 1 (DENV-1) (1)

Junin mammarenavirus (JUNV) (1)

Influenza A virus (Flu A) (5)

Orthohantavirus puumalaense (PUUV) (1)

Varicella-zoster virus (VZV/HHV-3) (4)

Mouse (33)

Dobrava-Belgrade virus (DOBV) (2)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

Poliovirus type 1 (PV1) (2)

Dengue virus type 2 (DENV-2) (8)

Dengue virus type 3 (DENV-3) (1)

Human papillomavirus 58 (HPV58) (3)

Human astrovirus-8 (HAtVs) (1)

Staphylococcus aureus (3)

Seoul virus (SEOV) (2)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

Lassa virus (LASV) (1)

Dengue virus type 4 (DENV-4) (1)

Hendra virus (HeV) (2)

Epstein-Barr virus (EBV/HHV-4) (2)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)

Hepatitis C Virus (HCV) (9)

Suid alphaherpesvirus 1 (SuHV-1/PRV) (2)

Human papillomavirus 16 (HPV16) (2)

Rotavirus (RV) (1)

Human immunodeficiency virus 1 (HIV-1) (9)

Human (177)

Andes virus (ANDV) (2)

Chikungunya virus (CHIKV) (1)

Nipah virus (NiV) (13)

Clostridium botulinum (2)

Hepatitis E virus/HEV (1)

Zika virus (ZIKV) (4)

Coxsackievirus B1 (CBV1) (3)

Zaire ebolavirus (ZEBOV) (6)

Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)

Rat (1)

E. coli (4)

Rotavirus A (RV-A) (3)

Human adenovirus 3 (HAdV-3) (1)

Sin Nombre virus (SNV) (2)

Human endogenous retroviruses W (HERV-W) (1)

Plasmodium vivax (2)

Human respiratory syncytial virus (HRSV) (12)

Campylobacter jejuni subsp. (1)

Bovine respiratory syncytial virus (BRSV) (2)

Reston ebolavirus (REBOV) (1)

Human papillomavirus 6 (HPV6) (1)

Human parvovirus B19 (HPV B19) (3)

Clostridioides difficile (2)

Bundibugyo ebolavirus (BDBV) (1)

Human herpesvirus 1 (HSV-1/HHV-1) (3)

Human metapneumovirus (HMPV) (4)

Dog (10)

Enterovirus 71 (EV71) (4)

Rabbit (2)

Human metapneumovirus (2)

Machupo virus (MACV) (1)

Tai Forest ebolavirus (TAFV) (1)

Porcine circovirus 2 (PCV2) (2)

Hantaan virus (HTNV) (2)

Human cytomegalovirus (HCMV/HHV-5) (7)

Ebola virus (EBOV) (1)

Cat (1)

Streptococcus pneumoniae (1)

Brazilian scorpion (1)
Applications

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FCM (120)

WB (59)

Western blot (1)

SPR (46)

FuncS (4)

in vivo CTLA-4 neutralization (2)

NK cell activation (1)

ICC (3)

in vivo intra-tumoral regulatory T cell depletion (2)

in vivo (2)

Blocking (2)

Antagonist (1)

BLI (4)

IF (22)

Nneutralization (1)

IHC (18)

in vivo study (1)

Neutralizatio (1)

DB (3)

Cell Isolation (1)

IP (9)

in vivo neutralization (5)

in vivo research (1)

Cell Depletion (1)

Neutralization (706)

in vivo neutrophil depletion (2)

RIA (1)

in vivo protection (1)

IB (1)

neutralizing (1)

ELISA (621)

in vivo MDSC depletion (2)

in vitro neutralization (1)

in vivo CD8+ T cell depletion (1)
Reactivity

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Puumala virus (1)

Clostridium perfringens (3)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Influenza A virus (H7N1) (1)

SARS-CoV (1)

Rabies virus (RABV) (6)

O’nyong’nyong virus (ONNV) (1)

Listeria monocytogenes (1)

Tick-borne encephalitis virus (1)

Bacteriophage H19B (2)

HCoV-229E (2)

Rat (5)

RD114 retrovirus (1)

Murine norovirus 1 (MNV) (1)

Parainfluenza virus 5 (PIV5) (1)

HCoV-OC43 (1)

Human metapneumovirus (HMPV) (1)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Clostridium botulinum (1)

Influenza A virus (H7N3) (2)

Dengue Virus type 1 (DENV-1) (1)

SARS-CoV-2 (1)

HSV-1 (3)

Hepatitis E virus (2)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Monkey (1)

Human astrovirus-2 (1)

Chikungunya virus (1)

Human cytomegalovirus (HCMV/HHV-5) (1)

HCoV-NL63 (1)

Human astrovirus-8 (HAtVs) (1)

Dengue Virus type 2 (DENV-2) (1)

HSV-2 (3)

Norwalk virus (3)

Chikungunya virus (CHIKV) (4)

Human papillomavirus 16 (HPV16) (13)

Naja kaouthia (1)

Human enterovirus 71 (EV71) (3)

Influenza A virus H7 subtype (2)

Coxsackievirus B1 (CVB1) (3)

Foot-and-mouth disease virus (FMDV) (2)

Norwalk virus (NV) (5)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

Human (57)

Hendra virus (1)

Influenza A virus (H7N9) (1)

Human coronavirus HKU1 (HCoV-HKU1) (1)

Dengue Virus type 3 (DENV-3) (1)

Staphylococcus aureus (3)

Streptococcus equisimilis (1)

Bacillus anthracis (2)

HIV-1 (1)

Mayaro virus(MAYV) (1)

IgG1b12 (1)

Scorpion (2)

E. coli (1)

Homo sapiens (Human) (1)

Japanese encephalitis virus (JEV) (2)

Crimean-Congo hemorrhagic fever virus (2)

Measles virus (MeV) (2)

Nipah virus (1)

Lassa virus (LASV) (16)

Sin Nombre Virus (1)

Dengue virus (1)

Human respiratory syncytial virus (HRSV) (5)

Influenza B virus (2)

Dengue Virus type 4 (DENV-4) (1)

Hendra virus (HeV) (12)

Hepatitis C Virus (HCV) (43)

Ross River Virus (RRV) (2)

MERS-CoV (2)

Coxsackievirus A16 (CVA16) (3)

Vaccinia virus (VACV) (20)

Venezuelan equine encephalitis virus (VEEV) (1)

Zika virus (1)

Yellow Fever Virus (YFV) (1)

Mexican scorpion (3)

Pig (1)

Nipah virus (NiV) (13)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

O'nyong'nyong virus (ONNV) (1)

Escherichia coli (1)

Epstein-Barr virus (EBV/HHV-4) (3)

Porcine circovirus 2 (PCV2) (1)

Guertu Virus (GTV) (3)

Clostridium tetani (1)

Canine parvovirus (1)

Western equine encephalitis virus (WEEV) (1)

Zika virus (ZIKV) (1)

Clostridioides difficile (2)

Junin mammarenavirus (JUNV) (3)

Influenza A virus (1)

Semliki Forest virus (SFV) (1)

Klebsiella pneumoniae (1)

Bovine viral diarrhea virus (BVDV) (2)

Monkeypox virus (MPXV) (12)

Mouse (25)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Heartland Virus (HRTV) (1)

Poliovirus type 1 (PV1) (1)

HAstV-1 (2)

Vesicular stomatitis Indiana virus (VSIV) (2)

Monkeypox virus (5)

Hepatitis E virus/HEV (3)

Eastern equine encephalitis virus (EEEV) (1)

Ophiophagus hannah (1)

West Nile virus (WNV) (1)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Corynephage omega (3)

Machupo virus (MACV) (1)

Theileria parva (1)
Host species

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Rabbit (2)

Mouse (215)

Human (463)

Dog (8)

Alpaca (23)

Cat (1)

Rat (10)
Clonality

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Monoclonal (727)
Conjugate

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Unconjugated (727)