Anti-CAV1 Polyclonal Antibody (HX089014)

Name: Anti-CAV1 Polyclonal Antibody
Brand: abinScience
SKU: HX089014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HX089014

Description

Anti-CAV1 Polyclonal Antibody (HX089014) is a rabbit polyclonal antibody detecting CAV1 in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Cat, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CAV1 (Ser2-Ser104).

Target

CAV, CAV1, Caveolin-1

Purification

Purified by antigen affinity column.

Accession

Q03135

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Caveolin-1 (CAV1) is a ~20 kDa protein. May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.

1. Vargas, L. et al. (2002) The Journal of biological chemistry 277, 9351-7. PMID: 11751885

2. McMahon, KA. et al. (2009) The EMBO journal 28, 1001-15. PMID: 19262564

3. Ohnuma, K. et al. (2007) The Journal of biological chemistry 282, 10117-10131. PMID: 17287217

4. Hwangbo, C. et al. (2016) Oncogene 35, 389-401. PMID: 25893292

Note

For research use only.

Images

References

Datasheet