Anti-Human CD169/SIGLEC1 Polyclonal Antibody (HV234014)

Name: Anti-Human CD169/SIGLEC1 Polyclonal Antibody
Brand: abinScience
SKU: HV234014
Price: 168 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HV234014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD169/SIGLEC1 (Gly34-Gly240).

Target

Siglec-1, CD169, SIGLEC1, SN, Sialic acid-binding Ig-like lectin 1, Sialoadhesin

Purification

Purified by antigen affinity column.

Accession

Q9BZZ2

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Sialoadhesin (CD169/SIGLEC1) is a ~182 kDa protein. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response. Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2. Acts as an endocytic receptor mediating clathrin dependent endocytosis.

1. Jones, C. et al. (2003) Molecular microbiology 49, 1213-25. PMID: 12940982

2. Benet, S. et al. (2021) Journal of extracellular vesicles 10, e12046. PMID: 33489013

3. Hammonds, JE. et al. (2017) PLoS pathogens 13, e1006181. PMID: 28129379

4. Perez-Zsolt, D. et al. (2021) Cellular & molecular immunology 18, 2676-2678. PMID: 34782760

5. Zheng, Q. et al. (2015) Cell research 25, 1121-36. PMID: 26358190

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human CD169/SIGLEC1 polyclonal antibody at 1ug/mL on recombinant Human CD169/SIGLEC1 (Catalog No. HV234012).

References

Datasheet